Densification-induced conductivity percolation in high-porosity pharmaceutical microcrystalline cellulose compacts

The percolation theory is established as a useful tool in the field of pharmaceutical materials science. It is shown that percolation theory, developed for analyzing insulator–conductor transitions, can be applied to describe imperfect dc conduction in pharmaceutical microcrystalline cellulose during densification. The system, in fact, exactly reproduces the values of the percolation threshold and exponent estimated for a three-dimensional random continuum. Our data clearly show a crossover from a power-law percolation theory region to a linear effective medium theory region at a cellulose porosity of ;0.7. © 2003 American Institute of Physics. @DOI: 10.1063/1.1539902#